Orthogonal Antibody Neutralization
When a pathogen is neutralized by a given monoclonal antibody, there is a natural selection towards variants that are no longer recognized. In a polyclonal response, multiple selective pressures are applied to a pathogen in concert. If this pressure occurs more quickly than the ability of a pathogen to evolve, it may be feasible to create a "checkmate" scenario that prevents escape. We are interested in applying this concept to ongoing HIV replication with existing neutralizing antibodies.