Perugino et al.
Cell Rep. 2025
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection
Publications
Research publications from The Balazs Laboratory covering immunology, viral pathogenesis, and therapeutic development.
Abul et al.
Geroscience 2025
Broad immunogenicity to prior SARS-CoV-2 strains and JN.1 variant elicited by XBB.1.5 vaccination in nursing home residents
Oyebanji et al.
Aging Clin Exp Res. 2025
COVID-19 booster doses reduce sex disparities in antibody responses among nursing home residents
Roederer et al.
Cell Rep Med. 2024
Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity
Galvez et al.
Viruses. 2024
QuickFit: A High-Throughput RT-qPCR-Based Assay to Quantify Viral Growth and Fitness In Vitro
Gravenstein et al.
EBioMedicine. 2024
Durability of immunity and clinical protection in nursing home residents following bivalent SARS-CoV-2 vaccination
Nitido et al.
Cell. 2024
mRNA-based monkeypox virus vaccine prevents disease in non-human primates
Hauser et al.
ACS Infect Dis. 2024
Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation
Wamhoff et al.
Nat Commun. 2024
Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Oyebanji et al.
J Am Geriatr Soc. 2023
Neutralization and binding antibody response to second bivalent COVID-19 vaccination in nursing home residents
Yeung et al.
Blood Adv. 2023
De novo hematopoiesis from the fetal lung
Dudley et al.
Vaccine. 2023
Rheumatoid arthritis and older age are associated with lower humoral and cellular immune response to primary series COVID-19 mRNA vaccine
Joshi et al.
Curr Opin HIV AIDS. 2023
Delivery platforms for broadly neutralizing antibodies
Meador et al.
Clin Lung Cancer. 2023
Brief Report: Declining Rates of SARS-CoV-2 Vaccine Uptake Among Patients With Thoracic Malignancies
Luthuli et al.
Virology. 2023
Generation and characterization of infectious molecular clones of transmitted/founder HIV-1 subtype C viruses
Nugent et al.
Vaccine. 2023
Second monovalent SARS-CoV-2 mRNA booster restores Omicron-specific neutralizing activity in both nursing home residents and health care workers
Yue et al.
Cell Rep Methods. 2023
Diagnostic TR-FRET assays for detection of antibodies in patient samples
Freeman et al.
Open Forum Infect Dis. 2023
Association of Cytomegalovirus Serostatus With Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responsiveness in Nursing Home Residents and Healthcare Workers
Canaday et al.
MMWR Morb Mortal Wkly Rep. 2023
SARS-CoV-2 Antibody Responses to the Ancestral SARS-CoV-2 Strain and Omicron BA.1 and BA.4/BA.5 Variants in Nursing Home Residents After Receipt of Bivalent COVID-19 Vaccine - Ohio and Rhode Island, September-November 2022
Atyeo et al.
Am J Obstet Gynecol. 2023
COVID-19 booster dose induces robust antibody response in pregnant, lactating, and nonpregnant women
Hauser et al.
Cell Rep Med. 2022
Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design
Backes et al.
J Exp Med. 2022
Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity
Burns et al.
Vaccines. 2022
BNT162b2 induces robust cross-variant SARS-CoV-2 immunity in children
Bartsch et al.
Sci trans Med. 2022
SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children
Canaday et al.
Clin Infect Dis. 2022
Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination
Hauser et al.
Front Immunol. 2022
Humoral responses to the SARS-CoV-2 spike and receptor binding domain in the context of pre-existing immunity confer broad sarbecovirus neutralization
Brady et al.
Sci Transl Med. 2022
Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized miceein A
Atyeo et al.
Nat Comm. 2022
Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms
Canaday et al.
eBioMed. 2022
COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents
Barmettler et al.
J Allergy Clin Immunol Pract. 2022
Response to Severe Acute Respiratory Syndrome Coronavirus 2 Initial Series and Additional Dose Vaccine in Patients With Predominant Antibody Deficiency
Casazza et al.
Nat Med. 2022
Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
Kenney et al.
Cell Rep. 2022
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection
Naranbhai et al.
J Infect Dis. 2021
Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines
Burns et al.
Vaccines. 2022
Durability and Cross-Reactivity of SARS-CoV-2 mRNA Vaccine in Adolescent Children
Hauser et al.
Cell Rep. 2022
Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting
Naranbhai et al.
Cell. 2022
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Vanuytsel et al.
Nat Comm. 2022
Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment
Calvet-Mirabent et al.
Eur J Immunol. 2022
Poly I:C and STING agonist-primed DC increase lymphoid tissue polyfunctional HIV-1-specific CD8+ T cells and limit CD4+ T-cell loss in BLT mice
Garcia-Beltran et al.
Cell. 2022
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Naranbhai et al.
Cancer Cell. 2022
Neutralization breadth of SARS-CoV-2 viral variants following primary series and booster SARS-CoV-2 vaccines in patients with cancer
Naranbhai et al.
J Clin Oncol. 2022
Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study
Bowes et al.
Radiother Oncol. 2021
Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy
Feldman et al.
Sci Immunol. 2021
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses
Canaday et al.
Clin Infect Dis. 2021
Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents
Oyebanji et al.
Aging Clin Exp Res. 2021
Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?
Phelps et al.
Front Immunol. 2021
Contribution to HIV Prevention and Treatment by Antibody-Mediated Effector Function and Advances in Broadly Neutralizing Antibody Delivery by Vectored Immunoprophylaxis
Garcia-Beltran et al.
Front Immunol. 2021
Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection
Cele et al.
Nature. 2021
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma
Garcia-Beltran et al.
Cell. 2021
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Schiff et al.
Sci Rep. 2021
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells
Yousif et al.
Immunity. 2021
The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells
Kisalu et al.
JCI Insight. 2021
Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention
Garcia-Beltran et al.
Cell. 2021
COVID-19-neutralizing antibodies predict disease severity and survival
Chen et al.
Cell. 2020
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
Roy et al.
J Imm Meth. 2020
SARS-CoV-2-specific ELISA development
Crawford et al.
Viruses 2020
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
Keating et al.
J Proteome Res. 2020
Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens
Huang et al.
PLoS One. 2019
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
van den Berg et al.
Mol Ther Meth Clin Dev. 2019
AAV-Mediated Expression of Broadly Neutralizing and Vaccine-like Antibodies Targeting the HIV-1 Envelope V2 Region
Welles et al.
PLoS Pathog. 2018
Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge
Lin et al.
Retrovirology 2018
Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1
Brady et al.
Immunol Rev. 2017
Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention
Payne et al.
Mol Ther Meth Clin Dev. 2016
Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy
Thomas et al.
Exp Hematol. 2016
Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57
Akkina et al.
AIDS Res Human Retr. 2016
Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary
Deal et al.
Cur Opin Immunol. 2015
Engineering humoral immunity as prophylaxis or therapy
Saunders et al.
J Virol. 2015
Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection
Deal et al.
Cur Opin HIV AIDS. 2014
Vectored antibody gene delivery for the prevention or treatment of HIV infection
de Jong et al.
Sci Transl Med. 2014
Broadly neutralizing antibodies abrogate established hepatitis C virus infection
Deal et al.
Proc Natl Acad Sci. USA 2014
Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice
Balazs et al.
Nat Med. 2014
Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
Balazs et al.
Nat Biotech. 2013
Broad protection against influenza infection by vectored immunoprophylaxis in mice
Balazs et al.
Nat Immunol. 2012
Antibody gene transfer for HIV immunoprophylaxis
Balazs et al.
Nature 2011
Antibody-based protection against HIV infection by vectored immunoprophylaxis
Sigal et al.
Nature 2011
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
Luo et al.
PLoS Pathog. 2010
Dimeric 2G12 as a potent protection against HIV-1
O'Connell et al.
Proc Natl Acad Sci. USA 2010
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
O'Connell et al.
PLoS ONE 2010
Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations
Austin et al.
J Clin Invest. 2008
Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome
Balazs et al.
Blood 2006
Endothelial Protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow
Michurina et al.
Mol Ther 2004
Nitric oxide is a regulator of hematopoietic stem cell activity
Balooch et al.
J. Biomed. Mater. Res. 1998
Viscoelastic properties of demineralized human dentin measured in water with atomic force microscope (AFM)-based indentation